BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

An interrogation of the term 'theory' from the perspective of linguistic discourse Zima offers a new definition of theory from a cultural and sociological perspective, with a view to encountering heterogenerous points of view in critical dialogue.

Presents an original theoretical system to explain and contrast modernism and postmodernism.

J. T. Hooker argues that at Il. 24.649 πικερτομων must mean ‘taunting’ and, since ‘taunting’ makes no sense, that πικερτομων must have entered our Iliad at this point from a version of the Iliad slightly different from ours in which it did make sense. I wish to argue that πικερτομων has a meaning different from ‘taunting’, which makes good sense of this, and every other, context.

Les colonies de Terre Sainte, en dépit de trois croisades successives, ont abordé le dernier quart du 13e siècle dans un état de faiblesse inquiétant. Le pape Grégoire X a essayé durant cinq ans de redresser la situation par tous les moyens. L'A. retrace tout d'abord la destinée exceptionnelle de ce pape, de son vrai nom Tebaldo Visconti, né à Plaisance en 1210 et mort à Arezzo en 1276. Il étudie ensuite l'action de Grégoire X dans son redressement spirituel de (...) l'Orient latin. Son désir profond de venir en aide à la Terre Sainte s'exprima aussi dans des mesures financières. Les limites de l'action du Saint-Siège sont étudiées ainsi que le soutien logistique des colonies franques de Syrie apporté au pape. L'évolution de la conjoncture internationale compromit sérieusement à partir de 1273 les retombées ses efforts. (shrink)

J. T. Hooker argues that at Il. 24.649 ⋯πικερτομ⋯ων must mean ‘taunting’ and, since ‘taunting’ makes no sense, that ⋯πικερτομ⋯ων must have entered ourIliadat this point from a version of theIliadslightly different from ours in which it did make sense. I wish to argue that ⋯πικερτομ⋯ων has a meaning different from ‘taunting’, which makes good sense of this, and every other, context.

We develop an axiomatic set theory — the Theory of Hyperfinite Sets THS— which is based on the idea of the existence of proper subclasses of large finite sets. We demonstrate how theorems of classical continuous mathematics can be transfered to THS, prove consistency of THS, and present some applications.

The gives the detailed analysis of the ratio of freedom and imagination in an unpublished manuscript written by F.V.Y. Schelling, which contains the materials for the lecture course read at Erlangen University in 1820-1821. The author focuses on the question of imagination as a condition for the possibility to unfold the modal differences that provide the hierarchy of predicative definitions. The article shows that both the draft philosophy of mythology and the philosophy of revelation are a direct continuation of the (...) transcendentalist program given by Kant.Those projects bases on the thesis that the consciousness of freedom and consciousness of the law, justified in the “Critique of Practical Reason”, are related one another. Schelling following Kant’s theory, points to the law and to the unconditional imperative of freedom as the main principle which is not only theoretical or practical, but determines the separation of ontological and deontological modalities. At the same time, the formal structure of an imperative as a command has the specific character of “hiden opening”: what is themed in an imperative is not opened as a meaningful opportunity, it is only opened as theopportunity in its difference from necessity. I show in this article that interpreting the Schelling possibility relies on the teachings of I. Kant in his transcendental idealconception, connected with Kant's interpretation of the imagination’s productive ability. In the middle of Schelling’s theological interpretation of Kant's consciousness of lawdoctrine as the “fact of mind” lies the analogy between peacemaking and the ancestral sin of the first people. This concept is the main source of the theory of potency as ontological modalities, developed by Schelling in the 1830s - 1840s in lectures on the philosophy of mythology and the philosophy of revelation. (shrink)